The investigation of signal transmission in brain requires to reproduce/observe physiological events that occur on a wide range of spatiotemporal scales, from e.g. the localized brief (μs) transient associated with asingle (sub micron) synaptic event to the complex arithmetic that dendrites use in integrating (μs-ms) multiple localizedsynaptic inputs (several micrometers apart).
Light microscopy is a fundamental tool in neuroscience offering a sensitive and non-invasive approach to probe and mimic such brain complexity.
The aim of this team is to develop a specific class of optical techniques based on spatiotemporal engineering of opticalwave-fronts obtained by phase modulation solely. This approach has the advantage of minimizing power losses, permitting a quick adaptability of the excitation pattern to the experimental context and allowing a true 3D sculpting of the excitation volumes.
The team activity is organized in four research lines:
- Spatiotemporal control of neuronal activity with patterned light
- Super resolution microscopy (STED) and scanning less microscopy
- Microendoscopy for awake animal imaging and for deep imaging
- Valentina Emiliani
- Phone: +33 (0) 1 42 86 42 53
Vincent de Sars, Valentina Emiliani, Benoît Forget, Marc Guillon, Eirini Papagiakoumou, Emiliano Ronzitti, Christophe Tourain, Dimitrii Tanese, Valeria Zampini, Marco Pascucci, Marta Gajowa, Lyle Graham, Alexis Picot, I-Wen Chen, Nicolo Accanto, Soledad Dominguez,
Osnath Assayag, Marcel Lauterbach, Aurélien Begue, Óscar Hernández Cubero, Erwan Ledoux, Vivien Szabo, Delphine Vardanega, Cathie Ventalon, Dalila Achemaoui, Emmanuelle Chaigneau, Amanda Foust, Léona Enke, Francesca Anselmi, Nidal Bouzekri, Aurianne Megdoud, Fabio Simony Conesa, Anthony Brureau,