The recent advent of genetically encoded photosensitive tools (optogenetics) and caged compounds offers today the possibility of stimulating and monitoring neuronal activity within intact neuronal circuits and systems with an unprecedented spatial and temporal precision. Moreover, these optogenetic and chemical tools allow to dissect complex cellular processes such as the maintenance of neuronal compartments (spines, axon, organelles), the homeostasis of neurotransmitters, and their dysfunction in neurological diseases.
This on-going revolution has motivated the development of new optical methods for light stimulation covering a wide range of spatial scales from the subcellular to the integrative level which has in turn stimulated new fundamental questions in cellular and integrative neuroscience.
To quickly progress in this revolution, it is essential that scientists with complementary backgrounds can share a common research environment and common scientific goals.
The aim of the Neurophotonics Laboratory, is to create such synergetic environment by bringing together research teams with complementary expertise ranging from advanced optics, non-linear microscopy, neurophysiology, cell biology, molecular biology and biophysics

Director : Valentina Emiliani
Phone: +33 (0) 1 42 86 42 53

Co-director : Bruno Gasnier
Phone: +33 (0) 1 70 64 99 15

Secretariat : Verena Todde
Phone: +33 (0) 1 42 86 21 31
Fax : +33 (0) 1 42 86 42 55

Paris Descartes University - Biomedical and Fundamental Science Faculty - CNRS

Neurophotonics laboratory, UMR8250
45 rue des Saints Pères
75270 Paris Cedex 06


Congratulation to Emmanuelle Chaigneau and al. for their lastest publication!

Two-Photon Holographic Stimulation of ReaChR Optogenetics provides a unique approach to remotely manipulate brain activity with light. Reaching the degree of spatiotemporal control necessary to (...)

Congratulation to Rossella Conti and al. for their lastest publication!

Computer Generated Holography with Intensity-Graded Patterns Computer Generated Holography achieves patterned illumination at the sample plane through phase modulation of the laser beam at the (...)

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