The recent advent of genetically encoded photosensitive tools (optogenetics) and caged compounds offers today the possibility of stimulating and monitoring neuronal activity within intact neuronal circuits and systems with an unprecedented spatial and temporal precision. Moreover, these optogenetic and chemical tools allow to dissect complex cellular processes such as the maintenance of neuronal compartments (spines, axon, organelles), the homeostasis of neurotransmitters, and their dysfunction in neurological diseases.
This on-going revolution has motivated the development of new optical methods for light stimulation covering a wide range of spatial scales from the subcellular to the integrative level which has in turn stimulated new fundamental questions in cellular and integrative neuroscience.
To quickly progress in this revolution, it is essential that scientists with complementary backgrounds can share a common research environment and common scientific goals.
The aim of the Neurophotonics Laboratory, is to create such synergetic environment by bringing together research teams with complementary expertise ranging from advanced optics, non-linear microscopy, neurophysiology, cell biology, molecular biology and biophysics

Director : Valentina Emiliani
Phone: +33 (0) 1 42 86 42 53

Co-director : Bruno Gasnier
Phone: +33 (0) 1 70 64 99 15

Secretariat : Elisa Sylla-Preira
Phone: +33 (0) 1 42 86 21 31
Fax : +33 (0) 1 42 86 42 55

Paris Descartes University - Biomedical and Fundamental Science Faculty - CNRS

Neurophotonics laboratory, UMR8250
45 rue des Saints Pères
75270 Paris Cedex 06


Contrôle optique de neurones uniques avec de la lumière sculptée et des opsines somatiques

"Les équipes de Valentina Emiliani au Laboratoire de neurophotonique et de Ed Boyden au MIT à Boston (USA), ont élaboré une nouvelle approche qui permet le contrôle spatial et temporel de l’activation (...)

Next-generation optogenetic molecules control single neurons

"Focused laser beam could help scientists map connections among neurons that underlie behavior." Extracted from MIT News MIT researchers have devised a way to control single neurons using (...)

Congratulation to Valeria Zampini et Dimitrii Tanese for their last publication in Nature Neuroscience !

Temporally precise single-cell-resolution optogenetics Optogenetic control of individual neurons with high tempo-ral precision within intact mammalian brain circuitry would enable powerful (...)

Training course : Optical control of brain functioning with optogenetics and wave front shaping

OBJECTIVES Be able to chose the most suitable combination of actuator, illumination methods and targeting strategy for each specific application Learn the skills and technologies required to (...)

Congratulation to Ronzitti and al. for their last publication in Journal of neuroscience!

Submillisecond Optogenetic Control of Neuronal Firing with Two-Photon Holographic Photoactivation of Chronos. Abstract: Optogenetic neuronal network manipulation promises to unravel a (...)

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