The recent advent of genetically encoded photosensitive tools (optogenetics) and caged compounds offers today the possibility of stimulating and monitoring neuronal activity within intact neuronal circuits and systems with an unprecedented spatial and temporal precision. Moreover, these optogenetic and chemical tools allow to dissect complex cellular processes such as the maintenance of neuronal compartments (spines, axon, organelles), the homeostasis of neurotransmitters, and their dysfunction in neurological diseases.
This on-going revolution has motivated the development of new optical methods for light stimulation covering a wide range of spatial scales from the subcellular to the integrative level which has in turn stimulated new fundamental questions in cellular and integrative neuroscience.
To quickly progress in this revolution, it is essential that scientists with complementary backgrounds can share a common research environment and common scientific goals.
The aim of the Neurophotonics Laboratory, is to create such synergetic environment by bringing together research teams with complementary expertise ranging from advanced optics, non-linear microscopy, neurophysiology, cell biology, molecular biology and biophysics

Director : Valentina Emiliani
Phone: +33 (0) 1 42 86 42 53

Co-director : Bruno Gasnier
Phone: +33 (0) 1 70 64 99 15

Secretariat : Verena Todde
Phone: +33 (0) 1 42 86 21 31
Fax : +33 (0) 1 42 86 42 55

Paris Descartes University - Biomedical and Fundamental Science Faculty - CNRS

Neurophotonics laboratory, UMR8250
45 rue des Saints Pères
75270 Paris Cedex 06


The International Human Frontier Science Program Organization (HFSPO) awards Valentina Emiliani.

She received the Research Grant Awardees 2016 for "Single cell-resolution imaging and optogenetics in the amygdala fear circuits in behaving animals"

For the first time, optical vortices of a high numerical aperture speckle pattern could be imaged thanks to superresolution STED microscopy.

The topological charge of vortices could be identified by modulating the axial field with impinging polarization. These results are expected to find applications for super-resolution microscopy (...)

See previous news...