The recent advent of genetically encoded photosensitive tools (optogenetics) and caged compounds offers today the possibility of stimulating and monitoring neuronal activity within intact neuronal circuits and systems with an unprecedented spatial and temporal precision. Moreover, these optogenetic and chemical tools allow to dissect complex cellular processes such as the maintenance of neuronal compartments (spines, axon, organelles), the homeostasis of neurotransmitters, and their dysfunction in neurological diseases.
This on-going revolution has motivated the development of new optical methods for light stimulation covering a wide range of spatial scales from the subcellular to the integrative level which has in turn stimulated new fundamental questions in cellular and integrative neuroscience.
To quickly progress in this revolution, it is essential that scientists with complementary backgrounds can share a common research environment and common scientific goals.
The aim of the Neurophotonics Laboratory, is to create such synergetic environment by bringing together research teams with complementary expertise ranging from advanced optics, non-linear microscopy, neurophysiology, cell biology, molecular biology and biophysics
Three-dimensional spatiotemporal focusing of holographic patterns. Abstract: Two-photon excitation with temporally focused pulses can be combined with phase-modulation approaches, such as (...)